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Survey of sinonasal inverted papillomata for Epstein‐Barr virus
Author(s) -
Dunn S. Terence,
Clark Gary D.,
Can Thomas C.,
Min KyungWhan
Publication year - 1997
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/(sici)1097-0347(199703)19:2<98::aid-hed3>3.0.co;2-p
Subject(s) - in situ hybridization , polymerase chain reaction , virus , epstein–barr virus , virology , biology , pathology , medicine , messenger rna , gene , genetics
Background Several studies have indicated an etiologic role for viruses in the development of sinonasal inverted papillomata (IP). A recent report demonstrates a strong relationship (65%) between Epstein‐Barr virus (EBV) and these lesions using polymerase chain reaction (PCR) analysis. Methods The present study analyzes a series of paraffin‐embedded tissues, comprising 25 surgically resected IPs and four fungiform papillomata (FP) for the presence of EBV using a sensitive in situ hybridization (ISH) assay and PCR. Results None of the specimens examined showed evidence of EBV infection by ISH, and only two papillomata (one sinonasal IP and one FP) gave positive reactions for EBV using PCR. Conclusions These data challenge the previous report and suggest that EBV is not a significant etiopathologic factor to be considered in the development of sinonasal IP. © 1997 John Wiley & Sons, Inc. Head Neck 19 : 98–106, 1997.