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Giant cell tumor of the larynx: Case report and review of the literature
Author(s) -
Werner Jochen A.,
Harms Dieter,
Beigel Arwed
Publication year - 1997
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/(sici)1097-0347(199703)19:2<153::aid-hed12>3.0.co;2-e
Subject(s) - larynx , giant cell , laryngectomy , differential diagnosis , atypia , medicine , giant cell tumors , nuclear atypia , laryngeal neoplasm , radiology , pathology , surgery , immunohistochemistry
Background Primary manifestation of a giant cell tumor (GCT) in the larynx is exceedingly rare. Until now, only 17 cases have been reported in the literature. Characterization of a GCT can be difficult partly because of similarities with the giant cell subtype of malignant fibrous histiocytoma (MFH). Methods The case of a 35‐year‐old man with a laryngeal GCT is presented. The patient underwent laryngectomy and has been free of recurrence since then (90 months). The literature is reviewed, and previously reported cases are presented in a table and compared with the presented case. The difficulties in the differential diagnosis are discussed. Conclusions When a laryngeal GCT is diagnosed, further differential diagnostic considerations should follow. One of these considerations is the MFH, which displays considerably more cellular atypia than GCT. Because most cases of giant cell MFH are high‐grade sarcomas, the distinction between GCT and MFH is necessary. © 1997 John Wiley & Sons, Inc. Head Neck 19 : 153–157, 1997.