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Tumor angiogenesis
Author(s) -
Petruzzelli Guy J.
Publication year - 1996
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/(sici)1097-0347(199605/06)18:3<283::aid-hed11>3.0.co;2-c
Subject(s) - angiogenesis , neovascularization , metastasis , cancer research , head and neck squamous cell carcinoma , chorioallantoic membrane , extracellular matrix , pathology , endothelial stem cell , lymphangiogenesis , medicine , biology , cancer , head and neck cancer , in vitro , microbiology and biotechnology , biochemistry
Background The growth of solid tumors, including head and neck squamous cell carcinomas, depends on the establishment of a blood supply within the tumor (neovascularization or angiogenesis). For this process to take place, tumors produce growth factors which stimulate the proliferation, migration, and differentiation of endothelial cells. These growth factors are polypeptides that preferentially bind heparan sulfate. In several tumor systems, the degree of angiogenesis can be correlated with tumor aggressiveness and clinical outcome. Results Head and neck squamous cell carcinomas produce an angiogenic response in the chick embryo chorioallantoic membrane assay. Additionally, supernatants from head and neck squamous cell carcinoma lines enhance endothelial cell proliferation and stimulate adhesion of endothelial cells to elements of the connective tissue matrix.