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Cytologic demonstration of “dysplastic” follicular dendritic cells in a case of hyaline‐vascular Castleman's disease
Author(s) -
Taylor Graeme B.,
Smeeton Ian W.M.I.
Publication year - 2000
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/(sici)1097-0339(200004)22:4<230::aid-dc6>3.0.co;2-5
Subject(s) - medicine , pathology , hyaline , follicular dendritic cells , cytology , follicular lymphoma , confusion , follicular phase , castleman disease , lymphoma , fine needle aspiration cytology , disease , immunology , psychology , immune system , t cell , antigen presenting cell , psychoanalysis , endocrinology
Large atypical follicular dendritic cells, considered dysplastic by some authors, were first described in association with Castleman's disease in 1991, but until now there has been no cytologic account regarding these cells. We report the cytologic and histologic findings of a case of hyaline‐vascular Castleman's disease associated with “dysplastic” follicular dendritic cells which presented as a mediastinal mass in a young man. The presence of giant cells within the preoperative fine‐needle aspirate specimen caused initial diagnostic uncertainty and their true nature was only confirmed retrospectively following application of an immunostain for CD21 to direct smears. Awareness of “dysplastic” follicular dendritic cells within aspirates of Castleman's disease will result in less cytological confusion in the future and may help to avoid the possibility of misdiagnosing Hodgkin's lymphoma which has certain cytologic similarities. Diagn. Cytopathol. 2000;22: 230–234. © 2000 Wiley‐Liss, Inc.