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Mesothelial hyperplasia with reactive atypia: Diagnostic pitfalls and role of immunohistochemical studies—a case report
Author(s) -
Lee Andrea,
Baloch Zubair W.,
Yu Gordon,
Gupta Prabodh K.
Publication year - 2000
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/(sici)1097-0339(200002)22:2<113::aid-dc12>3.0.co;2-6
Subject(s) - mesothelial cell , mesothelium , pathology , atypia , medicine , immunohistochemistry , mesothelioma , cytopathology , hyperplasia , cytology
The cytomorphologic features of highly reactive mesothelial cells can be difficult to distinguish from malignant cells. We report on an unusual case of mesothelial hyperplasia in a pericardial effusion. The specimen contained bizarre‐shaped cells and large tissue fragments in a patient with a history of lung carcinoma. The atypical cells were negative for CEA and LeuM‐1 and positive for cytokeratins (AE1/3) and HBME‐1. Strong HBME‐1 positivity supported a mesothelial origin of the atypical cells and led to the diagnosis of reactive mesothelium. While HBME‐1 cannot be used as the sole marker to establish an mesothelial origin; its use in a immunohistochemistry panel may be useful in individual cases to distinguish reactive mesothelial cells from carcinoma in effusion cytology. Diagn. Cytopathol. 2000;22:113–116. © 2000 Wiley‐Liss, Inc.