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Adenocarcinoma of the lung: Electron microscopy of fine‐needle aspiration biopsy specimens—a review of 73 cases
Author(s) -
Reyes Cesar V.,
Jensen JoAnne D.,
Graham Galen
Publication year - 1999
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/(sici)1097-0339(199905)20:5<257::aid-dc2>3.0.co;2-e
Subject(s) - adenocarcinoma , medicine , adenosquamous carcinoma , biopsy , pathology , lung , carcinoma , cytology , fine needle aspiration , cytopathology , cancer
During a 10‐yr period, 128 consecutive cases of pulmonary adenocarcinoma of varying differentiation were diagnosed with percutaneous fine‐needle aspiration biopsy. Sediments from the needle and syringe washings with 3% glutaraldehyde were obtained and processed for electron microscopic evaluation in 73 cases. Our results showed three types of adenocarcinoma: 62 cases of nonciliated bronchiolar cell origin, 6 cases of bronchioloalveolar cell origin, and 3 cases of mucous cell origin. In addition, there was an example of combined adenosquamous carcinoma and an instance of amphicrine carcinoma. Our study provided a more precise definition of the cytologic diagnosis and insight into the heterogeneity of lung adenocarcinoma. However, prognostic differences between cell types of lung adenocarcinoma were not observed. Diagn. Cytopathol. 1999;20:257–260. © 1999 Wiley‐Liss, Inc.