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Fine‐needle aspiration cytology in a case of isolated involvement of thyroid with Langerhans cell histiocytosis
Author(s) -
Sahoo Maheswar,
Karak Asis Kumar,
Bhatnagar Dinesh,
Sekhar Bal Chandra
Publication year - 1998
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/(sici)1097-0339(199807)19:1<33::aid-dc7>3.0.co;2-p
Subject(s) - medicine , langerhans cell histiocytosis , fine needle aspiration cytology , cytology , thyroid , pathology , histiocytosis , fine needle aspiration , histiocyte , dermatology , biopsy , disease
We present an unusual case of isolated thyroid involvement with Langerhans cell histiocytosis (LCH), diagnosed presumptively by fine‐needle aspiration (FNA) cytology and subsequently confirmed by immunohistochemistry in a 13‐yr‐old boy. The cytologic findings include high cellularity in a hemorrhagic background, the presence of characteristic mononucleated and multinucleated Langerhans cells with prominent nuclear grooves, and abundant foamy cytoplasm in a background of mixed eosinophilic and lymphocytic infiltrate, along with the presence of few focal aggregates of benign thyroid follicular cells. Further diagnostic confirmation was obtained by positive S‐100 protein immunohistochemistry of the Langerhans histiocytes on paraffin‐embedded sections of open thyroid biopsy of the prominently enlarged left lobe. We present the complete clinicopathologic features of this case, along with ultrasound, computerized axial tomographic, and technetium‐99 scan findings. We also discuss possible differential diagnostic consideration in light of a review of the literature and the role of FNA cytologic diagnosis in such a rare yet cytomorphologically characteristic case. Diagn. Cytopathol. 1998;19:33–37. © 1998 Wiley‐Liss, Inc.