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Isolated pleural effusion with hematopoietic cells of mixed lineage in a patient receiving granulocyte‐colony‐stimulating factor after high‐dose chemotherapy
Author(s) -
Busmanis Inny A.,
Beaty Anne E.,
Basser Russell L.
Publication year - 1998
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/(sici)1097-0339(199803)18:3<204::aid-dc8>3.0.co;2-d
Subject(s) - medicine , chemotherapy , granulocyte colony stimulating factor , haematopoiesis , pleural effusion , effusion , granulocyte , hematopoietic growth factor , lineage (genetic) , cancer research , oncology , immunology , stem cell , surgery , gene , genetics , biology
A 43‐yr‐old woman with recently diagnosed breast carcinoma presented with a right pleural effusion after a cycle of adjuvant, high‐dose chemotherapy supported by peripheral blood progenitor cells (PBPC) and granulocyte‐colony‐stimulating factor (G‐CSF, Filgrastim). Cytologic examination of the pleural aspirate yielded highly cellular material composed predominantly of cells of myeloid and macrophage/monocytic lineages. Despite clinical concern of a malignant effusion, the combination of cytologic and immunophenotypic examination yielded the correct diagnosis of a nonneoplastic effusion related to underlying pleural inflammation and possibly the administration of G‐CSF. Diagn. Cytopathol. 1998;18:204–207. © 1998 Wiley‐Liss, Inc.