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Cytologic specimens from the eye: A clinicopathologic study of 33 patients
Author(s) -
Fischler Diana F.,
Prayson Richard A.
Publication year - 1997
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/(sici)1097-0339(199710)17:4<262::aid-dc5>3.0.co;2-e
Subject(s) - medicine , cytology , malignancy , pathology , lymphoma , cryptococcosis , serology , immunology , antibody
Cytologic specimens from the eye (CSE) (fine‐needle aspirates and intraocular [vitrectomy] washings) are uncommon in most cytology practices. We reviewed our experience and diagnostic accuracy in lesions from this site over a 13‐yr period. Thirty‐three patients (12 males, 21 females, age 7–85 yr; mean 56 yr) were identified. Eighteen specimens were submitted to rule out malignancy. Of these, four CSE were positive, including melanoma (n = 1), large‐cell lymphoma (n = 2), and carcinoma (n = 1). None of the 14 patients with negative cytology showed clinical evidence of malignancy over a 1–28‐mo follow‐up period (mean, 8.4 mo). Fourteen specimens were submitted to rule out infectious agents. Cytology material contained culture‐proven organisms in one case each of Candida and Aspergillus. Of serology‐confirmed specimens, four CSE failed to reveal toxoplasma, and three lacked herpes viral inclusions. One case each of culture‐positive P. acnes and C. albicans lacked the organisms in the CSE. Twelve specimens were submitted to rule out inflammatory lesions. CSE showed chronic inflammation (n = 5), acute and chronic inflammation (n = 1), macrophages (n = 5), and nonnecrotizing granulomas (n = 1). Of 3 patients with sarcoidosis, CSE contained mature lymphocytes in all 3 cases, but no granulomas. Although the numbers are small, there is greater sensitivity in the detection of malignancy than of infectious agents. Diagn. Cytopathol. 1997;17:262–266. © 1997 Wiley‐Liss, Inc.