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Fine‐needle aspiration of epithelioid malignant peripheral nerve sheath tumor (epithelioid malignant schwannoma)
Author(s) -
Dodd Leslie G.,
Scully Sean,
Layfield Lester J.
Publication year - 1997
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/(sici)1097-0339(199709)17:3<200::aid-dc6>3.0.co;2-i
Subject(s) - medicine , schwannoma , malignant peripheral nerve sheath tumor , pathology , epithelioid cell , peripheral , fine needle aspiration , radiology , biopsy , immunohistochemistry
The epithelioid variant of malignant peripheral nerve sheath tumor (MPNST), also known as malignant epithelioid schwannoma, is a relatively rare and recently characterized clinicopathologic entity. The epithelioid variant of MPNST shares many clinical features with conventional MPNST but is characterized by different histologic and cytologic features. These include a distinctive nesting pattern and an abundance of cytoplasm not seen in histology of conventional nerve sheath tumors. Cytologically, the epitheliod variant shows a propensity to cellular discohesiveness and a plasmacytoid or epitheliod appearance that is in contradistinction to the spindled appearance of the usual MPNST. Herein, we report our experience with fine‐needle aspiration (FNA) of two epithelioid malignant schwannomas and discuss the FNA cytologic differential diagnosis. Diagn. Cytopathol. 1997;17:200–204. © 1997 Wiley‐Liss, Inc.