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Massive crystal‐storing histiocytosis associated with low‐grade malignant B‐cell lymphoma of MALT‐Type of the parotid gland
Author(s) -
Llobet Montserrat,
Castro Pilar,
Barceló Cristina,
Trull Jose Maria,
Campo Elias,
Bernadó Luis
Publication year - 1997
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/(sici)1097-0339(199708)17:2<148::aid-dc12>3.0.co;2-g
Subject(s) - pathology , histiocyte , medicine , lymphoma , malt lymphoma , parotid gland , malignant histiocytosis , histiocytosis , lymph node , b cell , cytopathology , eosinophilic , antibody , cytology , immunology , disease
Massive crystal deposition is unusual in lymphoproliferative disorders. In this report, a mucosa‐associated lymphoid tissue (MALT) low‐grade B‐cell lymphoma of the parotid gland containing large numbers of crystal‐storing histiocytes is described. The patient, an 81‐yr‐old female, presented with a history of long‐standing left parotid gland enlargement. FNA cytology of the tumor showed a lymphoplasmacytic infiltrate and sheets of large benign histiocytes with abundant eosinophilic intracytoplasmic inclusions. Paraffin‐section immunohistochemistry performed on the cell block demonstrated that the histiocytic cells were immunoreactive for the KP‐1 (CD‐68) antibody and monotypic for cytoplasmic IGM and L‐light chain. The cytological diagnosis was consistent with a low‐grade B‐cell lymphoma with plasmacytic differentiation associated with crystal‐storing histiocytosis. A periparotid lymph node was biopsied and showed involvement by a monocytoid B‐cell lymphoma with plasmacytic differentiation and crystal‐storing histiocytosis in the pericapsular region. Diagn. Cytopathol. 17:148–152, 1997. © 1997 Wiley‐Liss, Inc.