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Complementary value of five carcinoma markers for the diagnosis of malignant mesothelioma, adenocarcinoma metastasis, and reactive mesothelium in serous effusions
Author(s) -
Delahaye Mick,
van der Ham Frieda,
van der Kwast Theo H.
Publication year - 1997
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/(sici)1097-0339(199708)17:2<115::aid-dc6>3.0.co;2-f
Subject(s) - mesothelioma , medicine , serous fluid , pathology , immunostaining , metastasis , metastatic carcinoma , carcinoma , adenocarcinoma , stain , mesothelium , immunohistochemistry , serous membrane , staining , mesothelial cell , cancer
Cytological slides of serous fluids of 41 malignant mesotheliomas, 88 metastatic adenocarcinomas, and 25 reactive effusions were immunostained with the antibodies anti‐CEA, MOC‐31, Leu‐M1, Ber‐EP4, and B72.3. Most mesotheliomas and all reactive fluids failed to stain with these antibodies. The sensitivity of the five markers to detect carcinoma cells differed remarkably. Especially MOC‐31, Ber‐EP4, and B72.3 stained with a high number of carcinoma cases and the complementary value of Ber‐EP4 and B72.3 to immunostain carcinoma cells was impressive: 94% of the metastatic adenocarcinoma cases reacted with Ber‐EP4 or B72.3 in contrast to 1 of 41 malignant mesotheliomas. Diagn. Cytopathol. 17:115–120, 1997. © 1997 Wiley‐Liss, Inc.