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Scrape cytology of pemphigus vulgaris of the nipple, a mimicker of Paget's disease
Author(s) -
Kobayashi Tadao K.,
Ueda Masami,
Nishino Toshihiro,
Kibe Sachiko,
Higashida Takashi,
Watanabe Shinsuke
Publication year - 1997
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/(sici)1097-0339(199702)16:2<156::aid-dc13>3.0.co;2-l
Subject(s) - immunoperoxidase , pathology , pemphigus vulgaris , medicine , immunocytochemistry , cytology , antibody , anatomy , immunology , monoclonal antibody
A case of histologically and immunocytochemically confirmed pemphigus vulgaris of the nipple examined by scrape cytology is reported. The scrape cytology showed isolated and somewhat loosely clustered cells with basophilic cytoplasm and vesicular hyperchromatic nuclei dysplaying prominent nucleoli, suggesting Paget's disease of the nipple. However, histological examination of the resected tissue together with the direct immunofluorescence technique for demonstration of in vivo‐bound immunoglobulin to epithelium confirmed the diagnosis of pemphigus vulgaris. The use of an immunoperoxidase stain for IgG on the Papaniolaou‐destained smear also gave a positive reaction on the cell membranes and provided a precise cellular diagnosis of the lesions. Cytodiagnostic pitfalls of these rare breast lesions are discussed, as well as the diagnostic value of immunocytochemistry. Diagn. Cytopathol. 16:156–159, 1997. © 1997 Wiley‐Liss, Inc.