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Cytologic features of deep juvenile xanthogranuloma
Author(s) -
Grenko Ronald T.,
Sickel Joshua Z.,
Abendroth Catherine S.,
Cilley Robert E.
Publication year - 1996
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/(sici)1097-0339(199611)15:4<329::aid-dc15>3.0.co;2-q
Subject(s) - juvenile xanthogranuloma , histiocyte , giant cell , medicine , pathology , lesion , cd68 , cytopathology , cytology , fine needle aspiration , biopsy , immunohistochemistry
Juvenile xanthogranuloma (JXG) is a rare lesion of the skin and deep tissues whose cytologic features have not previously been published. We report on 2 cases of JXG in patients aged 5 days and 5 yr who presented with an axillary mass and enlarged supraclavicular lymph node, respectively. Fine‐needle aspiration and touch imprints made from the surgical biopsies yielded cellular specimens composed of histiocytes, multinucleated Touton‐type giant cells, and variable admixtures of lymphocytes and eosinophils. One lesion was composed primarily of benign‐appearing histiocytes with admixed multinucleated giant cells and a few lymphocytes. The second lesion consisted of a few histiocytes, occasional Touton giant cells, many lymphocytes, and scattered fibroblasts. The histiocytes were CD68‐positive and S100‐negative. Histologic follow‐up confirmed the diagnosis of juvenile xanthogranuloma. One patient was lost to follow‐up; the other is alive without evidence of recurrence 1 yr after surgery. We conclude that deep JXG has characteristic and diagnostic cytologic features. Diagn Cytopathol 1996;15:329–333. © 1996 Wiley‐Liss, Inc.