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Preoperative assessment of proliferative activity and hormonal receptor status in carcinoma of the breast: A comparison of needle aspiration and needle‐core biopsies to the surgical specimen
Author(s) -
Railo Mikael,
Nordling Stig,
Krogerus Leena,
Sioris Thanos,
von Smitten Karl
Publication year - 1996
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/(sici)1097-0339(199609)15:3<205::aid-dc6>3.0.co;2-f
Subject(s) - medicine , fine needle aspiration , breast carcinoma , biopsy , core biopsy , carcinoma , estrogen receptor , progesterone receptor , pathology , breast cancer , urology , cancer
The applicability and reliability of estimates of proliferative activity in breast carcinomas using fine‐needle aspiration (FNA) and needle‐core biopsies (NC) was evaluated in 98 breast carcinoma patients. The Ki‐67, Estrogen receptor (ER), and progesterone receptor (PR) immunolabelling of FNA and NC was compared with that of the surgical specimen. A statistically significant consistency between labelling was found in the Ki‐67‐NC (κ=0.474), ER‐FNA (κ=0.318), ER‐NC (κ=0.518), and PR‐FNA (κ=0.404) groups. The consistency in the Ki‐67‐FNA group was less significant (κ=0.182), and there was no consistency in the PR‐NC group (κ=0.062). There was a positive correlation of Ki‐67 labelling in FNA and NC biopsies (Spearman rank, p=0.4; P=0.0007), and also in ER labeling (Spearman rank p=0.6; P=0.0001. These results indicate that NC and FNA can be used for preoperative assessment of proliferative activity and hormonal status in breast carcinoma. Diagn Cytopathol 1996; 15:205–210. © 1996 Wiley‐Liss, Inc.