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Streamlined synthesis of substituted 2‐Aminothiazoles using tandem precipitative and polymer‐assisted reactions
Author(s) -
Yun Young K.,
Leung Simon S. W.,
Porco John A.
Publication year - 2000
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/(sici)1097-0290(200024)71:1<9::aid-bit3>3.0.co;2-#
Subject(s) - tandem , chemistry , combinatorial chemistry , materials science , composite material
The tactical combination of classical product precipitation and subsequent modification of precipitated products using polymer‐assisted transformations has been employed in the preparation of substituted 2‐aminothiazole derivatives. 2‐aminothiazoles were precipitated in parallel as hydrobromide monohydrate salts, directly redissolved, and reacted further using polymer‐supported reagents to afford free‐based 2‐aminothiazoles, aminothiazoyloxamates, and aminothiazoylamides. © 2000 John Wiley & Sons, Inc. Biotechnol Bioeng (Comb Chem) 71:9–18, 2000.