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Two‐phase model of the kinetics of growth of Rhizopus oligosporus in membrane culture
Author(s) -
Ikasari Lilik,
Mitchell David A.
Publication year - 2000
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/(sici)1097-0290(20000620)68:6<619::aid-bit4>3.0.co;2-e
Subject(s) - exponential growth , kinetics , acceleration , phase (matter) , exponential function , growth model , steady state (chemistry) , constant (computer programming) , hypha , thermodynamics , exponential decay , mechanics , kinetic energy , chemistry , mathematics , biological system , physics , biology , botany , mathematical analysis , computer science , classical mechanics , nuclear physics , organic chemistry , mathematical economics , programming language
An empirical model was developed to describe a growth profile occurring in solid‐state fermentation (SSF), namely that consisting of an initial period of rapid acceleration followed by an extended period of deceleration. This kinetic profile is not adequately described by the logistic model. The empirical model is based on the concept of active and nonactive hyphal segments. Exponential and deceleration growth phases are modeled. The model parameters can be determined directly from the dry‐weight profile and they depend on the growth medium present. The model suggests that, at the instant the culture enters the deceleration phase, there is a 71% to 86% decrease in the number of actively extending hyphal tips and that, during the deceleration phase, there is an exponential decay in the number of active hyphal segments, with a first‐order decay constant of 0.042 to 0.072 h −1 . © 2000 John Wiley & Sons, Inc. Biotechnol Bioeng 68: 619–627, 2000.