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Simple diffusion is the primary mechanism for glucose uptake during the production phase of the Aspergillus niger citric acid process
Author(s) -
Wayman F. M.,
Mattey M.
Publication year - 2000
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/(sici)1097-0290(20000220)67:4<451::aid-bit8>3.0.co;2-4
Subject(s) - aspergillus niger , citric acid , fermentation , chemistry , diffusion , glucose uptake , facilitated diffusion , biochemistry , membrane , biology , microbiology and biotechnology , thermodynamics , insulin , physics
Models for the known glucose transporters in Aspergillus niger and for simple diffusion of glucose through the hyphal membrane were prepared. The results from the models were compared with fermentation data from published studies on citric acid. It was found that the purely physical and uncontrolled process of diffusion could explain the specific rate of glucose uptake observed during the production phase in several different types of fermentation. © 2000 John Wiley & Sons, Inc. Biotechnol Bioeng 67: 451–456, 2000.