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Synthesis of sugar fatty acid esters by modified lipase
Author(s) -
Tsuzuki Wakako,
Kitamura Yoshiaki,
Suzuki Tateo,
Kobayashi Shoichi
Publication year - 1999
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/(sici)1097-0290(19990805)64:3<267::aid-bit2>3.0.co;2-b
Subject(s) - lipase , sugar , chemistry , fatty acid , triacylglycerol lipase , biochemistry , organic chemistry , food science , enzyme
A simple synthesis of sugar fatty acid esters was developed in a nonaqueous solution using lipase modified by synthetic detergent. Esterification of sugar was accelerated by continuous removal of water from the reaction mixture with a molecular sieve. When glucose and palmitic acid (1:1 by mole) were used as the starting substrates, more than 90% of glucose was converted to its ester in this system. The resultant product was 6‐ O ‐palmitoylglucose. Other mono‐ or disaccharides were also esterified by the modified lipase with high yield. It was shown that the modified lipase might act as a catalyst for the synthesis of sugar fatty acid esters. © 1999 John Wiley & Sons, Inc. Biotechnol Bioeng 64: 267–271, 1999.