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Solid‐state fermentation in rotating drum bioreactors: Operating variables affect performance through their effects on transport phenomena
Author(s) -
Stuart D. M.,
Mitchell D. A.,
Johns M. R.,
Litster J. D.
Publication year - 1999
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/(sici)1097-0290(19990520)63:4<383::aid-bit1>3.0.co;2-n
Subject(s) - bioreactor , solid state fermentation , bran , mass transfer , fermentation , substrate (aquarium) , aspergillus oryzae , chemistry , heat transfer , mixing (physics) , rotational speed , chemical engineering , materials science , chromatography , pulp and paper industry , food science , biology , mechanics , mechanical engineering , engineering , raw material , ecology , physics , organic chemistry , quantum mechanics
Aspergillus oryzae ACM 4996 was grown on an artificial gel‐based substrate and on steamed wheat bran during solid‐state fermentations in 18.7 L rotating drum bioreactors. For gel fermentations fungal growth decreased as rotational speed increased, presumably due to increased shear. For wheat bran fermentations fungal growth improved under agitated compared to static culture conditions, due to superior heat and mass transfer. We conclude that the effects of operational variables on the performance of SSF bioreactors are mediated by their effects on transport phenomena such as mixing, shear, heat transfer, and mass transfer within the substrate bed. In addition, the substrate characteristics affect the need for and the rates of these transport processes. Different transport phenomena may be rate limiting with different substrates. This work improves understanding of the effects of bioreactor operation on SSF performance. © 1999 John Wiley & Sons, Inc. Biotechnol Bioeng 63: 383–391, 1999.