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Dynamic reoptimization of a fed‐batch fermentor
Author(s) -
Iyer Mahesh S.,
Wiesner Theodore F.,
Rhinehart R. Russell
Publication year - 1999
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/(sici)1097-0290(19990405)63:1<10::aid-bit2>3.0.co;2-c
Subject(s) - fermentation , biochemical engineering , fed batch culture , batch processing , computer science , process (computing) , process engineering , work (physics) , adaptation (eye) , chemistry , biology , engineering , biochemistry , mechanical engineering , neuroscience , programming language , operating system
Traditionally, fed‐batch biochemical process optimization and control use complicated models and off‐line optimizers with no on‐line model adaptation and re‐optimization. This work demonstrates the applicability, effectiveness, and economic potential, of a simple phenomenological model for modeling, and a novel optimizer for on‐line re‐optimization and control of an aerobic fed‐batch fermentor. © 1999 John Wiley & Sons, Inc. Biotechnol Bioeng 63: 10–21, 1999.