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Resistance of biofilms to the catalase inhibitor 3‐amino‐1,2,4‐triazole
Author(s) -
Liu Xiaofeng,
Roe Frank,
Jesaitis Al,
Lewandowski Zbigniew
Publication year - 1998
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/(sici)1097-0290(19980720)59:2<156::aid-bit3>3.0.co;2-g
Subject(s) - catalase , biofilm , hydrogen peroxide , microbiology and biotechnology , peroxidase , pseudomonas fluorescens , superoxide dismutase , bacteria , chemistry , pseudomonas aeruginosa , enzyme , biochemistry , biology , genetics
Consortia of catalase positive bacteria consisting of Pseudomonas aeruginosa, Pseudomonas fluorescens, and Klebsiella pneumoniae, in both the planktonic form and as biofilms, disproportionate hydrogen peroxide into oxygen and water. The biofilm, however, continued to disproportionate the hydrogen peroxide in the presence of the catalase inhibitor, 3‐amino‐1,2,4‐triazole, while the planktonic organisms did not. While the bacterial catalase–peroxidase–dismutase system was probably responsible for the disproportionation of hydrogen peroxide in both cases, biofilms resisted inhibition of this enzyme system. © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng 59: 156–162, 1998.