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Dendrimer construction and macromolecular property modification via combinatorial methods
Author(s) -
Newkome George R.,
Childs Bradley J.,
Rourk Michael J.,
Baker Gregory R.,
Moorefield Charles N.
Publication year - 1999
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/(sici)1097-0290(1998)61:4<243::aid-cc6>3.0.co;2-a
Subject(s) - dendrimer , macromolecule , monomer , isocyanate , polymer science , chemistry , combinatorial chemistry , nanotechnology , materials science , polymer chemistry , polymer , organic chemistry , polyurethane , biochemistry
The design and utility of a family of isocyanate functionalized branched monomers, as well as others, are described. Use of these monomers in logical combinations for the construction of branched architectures leads to the formation of unique, asymmetric dendritic species possessing multiple functionalities. Ramifications of this combinatorial‐based, macromolecular construction technique are discussed with respect to functional group positioning and the potential to create dynamic heterogenous surfaces resembling a molecular “Rubik's sphere.” © 1999 John Wiley & Sons, Inc. Biotechnol Bioeng (Comb Chem) 61:243–253, 1998/1999.