Premium
Mini‐review: Proactive biomaterials and bone tissue engineering
Author(s) -
Dee Kay C,
Bizios Rena
Publication year - 2000
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/(sici)1097-0290(19960520)50:4<438::aid-bit11>3.0.co;2-f
Subject(s) - tissue engineering , bone tissue , biomedical engineering , nanotechnology , biochemical engineering , microbiology and biotechnology , chemistry , materials science , biology , medicine , engineering
Recent advances in cell isolation and culture procedures, combined with growing understanding and use of molecular biology and biochemistry techniques, have resulted in the establishment of a new field of biological/biomedical research: cellular and tissue engineering. In the biomaterials field, cell and tissue bioengineers are investigating the development of proactive biomaterials (for example, bioceramics, chemically modified implant metals, and biodegradable tissue scaffolds) which utilize cellular‐ or molecular‐level methods of manipulating cell/tissue behavior in order to encourage clinically desirable biological events at the tissue‐implant interface. In vitro investigations utilizing osteoblasts, osteoclasts, and appropriate precursor cells, combined with long‐term (i.e., years) tissue engineering studies in vivo are needed to enhance current understanding of the many mechanisms involved in bone formation and regulation. Such understanding will allow the development of proactive biomaterials for use in bone, which can elicit specific, timely, and clinically desirable responses from surrounding cells and tissues. © 1996 John Wiley & Sons, Inc.