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Conformations of oligoprolines with different configurational sequences and their association complexes with alkali and alkali‐earth ions
Author(s) -
De Santis Pasquale,
Palleschi Antonio,
Scipioni Anita,
Camalli Mercedes,
Spagna Riccardo,
Zanotti Giancarlo
Publication year - 1998
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/(sici)1097-0282(199803)45:3<257::aid-bip8>3.0.co;2-q
Subject(s) - chemistry , alkali metal , ion , alkaline earth metal , crystallography , nuclear magnetic resonance spectroscopy , solid state , conductance , stereochemistry , inorganic chemistry , organic chemistry , mathematics , combinatorics
To clarify the possible molecular mechanism of cation unit conductance of poly( D , L ‐proline) across lipidic membranes, the structure and conformation of tetraproline derivatives with different configurational sequences in solid state, as well as in solution and in the presence of alkali and alkali‐earth ions, were investigated using x‐ray analysis, CD, and nmr spectroscopy. The tetraproline derivatives Boc( D ‐Pro‐ L ‐Pro‐ L ‐Pro‐ D ‐Pro)OBg and Boc( L ‐Pro) 4 OBg show very different conformational versatilities in solutions as well as different propensities to form complexes with Ca 2+ ion. This is interpreted, based on previous evidence, as due to different abilities to form ion complexing cavities. © 1998 John Wiley & Sons, Inc. Biopoly 45: 257–267, 1998