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Saccharide–RNA recognition
Author(s) -
Hermann Thomas,
Westhof Eric
Publication year - 1998
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/(sici)1097-0282(1998)48:2<155::aid-bip5>3.0.co;2-i
Subject(s) - chemistry , ribozyme , rna , aminoglycoside , ligase ribozyme , computational biology , biochemistry , antibiotics , gene , biology
Among saccharides, the antibiotics of the aminoglycoside family are the best‐studied class of molecules interacting with RNA. By binding to RNA targets, aminoglycosides act as inhibitors of protein biosynthesis, they interfere with protein–RNA interaction of retroviral regulatory elements, and they inhibit the catalytic action of ribozymes. Here, we survey the available data on molecular structural details of aminoglycoside–RNA interaction. © 1999 John Wiley & Sons, Inc. Biopoly 48: 155–165, 1998