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Reading DNA differently
Author(s) -
Gat Yahaloma,
Lynn David G.
Publication year - 1998
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/(sici)1097-0282(1998)48:1<19::aid-bip3>3.0.co;2-i
Subject(s) - chemistry , reading (process) , dna , computational biology , biochemistry , linguistics , biology , philosophy
Product inhibition has provided the limiting barrier to efficient template‐directed ligation and polymerization reactions. Here we review the attempts to circumvent this limitation and outline a traslation strategy that does overcome the barrier and allows the information encoded in DNA to be read and amplified into backbone‐modified oligonucleotides. © 1998 John Wiley & Sons, Inc. Biopoly 48: 19–28, 1998