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Animal antimicrobial peptides: An overview
Author(s) -
Andreu David,
Rivas Luis
Publication year - 1998
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/(sici)1097-0282(1998)47:6<415::aid-bip2>3.0.co;2-d
Subject(s) - multicellular organism , antimicrobial peptides , innate immune system , computational biology , antimicrobial , mechanism (biology) , chemistry , mode of action , antibiotics , biology , immune system , microbiology and biotechnology , immunology , biochemistry , cell , epistemology , philosophy
Antibiotic peptides are a key component of the innate immune systems of most multicellular organisms. Despite broad divergences in sequence and taxonomy, most antibiotic peptides share a common mechanism of action, i.e., membrane permeabilization of the pathogen. This review provides a general introduction to the subject, with emphasis on aspects such as structural types, post‐translational modifications, mode of action or mechanisms of resistance. Some of these questions are treated in depth in other reviews in this issue. The review also discusses the role of antimicrobial peptides in nature, including several pathological conditions, as well as recent accounts of their application at the preclinical level. © 1999 John Wiley & Sons, Inc. Biopoly 47: 415–433, 1998