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Solid‐phase synthesis on planar supports
Author(s) -
Lebl Michal
Publication year - 1998
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/(sici)1097-0282(1998)47:5<397::aid-bip6>3.0.co;2-u
Subject(s) - planar , chemistry , sequence (biology) , solid phase synthesis , cellulose , phase (matter) , membrane , nanotechnology , molecule , polymer science , combinatorial chemistry , organic chemistry , materials science , computer science , peptide , biochemistry , computer graphics (images)
Planar supports represent a unique opportunity in designing novel approaches to solid‐phase synthesis of peptides and small organic molecules. Published work includes assembly on cellulose paper sheets, cotton strips, or membranes, as well as ultrahigh‐density synthesis on glass supports. Planar carriers allow for the synthesis to be performed without any reaction vessels (inclusion volume chemistry), construction of libraries with only one representation of each structure, or for continuous synthesis (replacing sequence in time by sequence in space). © 1999 John Wiley & Sons, Inc. Biopoly 47: 397–404, 1998