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Progress in the design of DNA sequence‐specific lexitropsins
Author(s) -
Walker Wynn L.,
Kopka Mary L.,
Goodsell David S.
Publication year - 1997
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/(sici)1097-0282(1997)44:4<323::aid-bip2>3.0.co;2-0
Subject(s) - chemistry , sequence (biology) , computational biology , dna , nanotechnology , biochemistry , materials science , biology
Sequence‐specific polyamides that bind in the minor groove of DNA are attractive candidates for antibiotics, cancer chemotherapeutics, and transcriptional antagonists. This paper reviews the progress of structure‐based design of minor‐groove‐binding polyamides, from the first structure of netropsin with DNA, to the effective linked polyamides currently under study. A theory of polyamide specificity is also reviewed, introducing methods to determine the optimal strategies for targeting a given DNA sequence within a genome of competing sequences. © 1998 John Wiley & Sons, Inc. Biopoly 44: 323–334, 1997