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Molecular and biological constraints on ligand‐binding affinity and specificity
Author(s) -
Szwajkajzer Danuta,
Carey Jannette
Publication year - 1997
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/(sici)1097-0282(1997)44:2<181::aid-bip5>3.0.co;2-r
Subject(s) - chemistry , ligand (biochemistry) , function (biology) , organism , macromolecule , computational biology , biochemistry , receptor , evolutionary biology , genetics , biology
Interactions between biological macromolecules have characteristic values of affinity and specificity that are set according to the biological function that is served by the interaction in the organism. Here we examine the molecular mechanisms that are used to achieve the required values of affinity and specificity in various biological systems. © 1997 John Wiley & Sons, Inc. 44: 181–198, 1997