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Crystallographic insights into DNA minor groove recognition by drugs
Author(s) -
Neidle Stephen
Publication year - 1997
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/(sici)1097-0282(1997)44:1<105::aid-bip7>3.0.co;2-z
Subject(s) - minor groove , groove (engineering) , minor (academic) , chemistry , sequence (biology) , hydrogen bond , dna , oligonucleotide , stereochemistry , crystallography , biochemistry , molecule , materials science , organic chemistry , political science , law , metallurgy
This review surveys the crystal structures between minor groove drugs and oligonucleotides, of which over thirty have now been determined. The various factors that are involved in the observed A/T sequence selectivity of these drugs are examined in structural terms. The roles of, in particular, hydrogen‐bond recognition and sequence‐dependent groove width, are assessed, and as a consequence the minor groove drugs have been classified into two categories, dependent on the relative roles played by these two factors in sequence recognition. Implications for the recognition of non‐A/T sequences are discussed. © 1997 John Wiley & Sons, Inc. Biopoly 44: 105–121, 1997