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Mass spectrometry, high performance liquid chromatography, and brain peptides
Author(s) -
Desiderio Dominic M.
Publication year - 1996
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/(sici)1097-0282(1996)40:3<257::aid-bip1>3.0.co;2-v
Subject(s) - chemistry , chromatography , high performance liquid chromatography , mass spectrometry , opioid peptide , tandem mass spectrometry , liquid chromatography–mass spectrometry , neuropeptide , qualitative analysis , opioid , biochemistry , receptor , qualitative research , social science , sociology
Abstract This paper is a personal recollection of some of the events and research that surrounded the amino acid sequence determination of the hypothalamic releasing factor, TRF (now known as TRH), by mass spectrometry (MS), and the development of reverse phase high performance liquid chromatography (RP‐HPLC) MS and tandem MS (MS/MS) methods for the qualitative and quantitative analysis of native opioid neuropeptides in human pituitary tissue extracts. © 1996 John Wiley & Sons, Inc.