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Is silicosis required for silica‐associated lung cancer?
Author(s) -
Checkoway Harvey,
Franzblau Alfred
Publication year - 2000
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/(sici)1097-0274(200003)37:3<252::aid-ajim2>3.0.co;2-#
Subject(s) - silicosis , medicine , lung cancer , pneumoconiosis , occupational exposure , pathology , environmental health
Background Abundant epidemiologic and experimental evidence supports the 1997 International Agency for Research on Cancer classification of crystalline silica as a human lung carcinogen. Nonetheless, there remains uncertainty about whether excessive lung cancer occurs exclusively among workers with silicosis. Methods A review was performed of published occupational epidemiologic literature directly pertinent to the interrelations among silica exposure, silicosis, and lung cancer. Results The association between silica and lung cancer is generally, but not uniformly, stronger among silicotics than nonsilicotics. However, the existing literature is ambiguous due to incomplete or biased ascertainment of silicosis, inadequate exposure assessment, and the inherently strong correlation between silica exposure and silicosis which hinders efforts to disentangle unique contributions to lung cancer risk. Conclusions Until more conclusive epidemiologic findings become available, population‐based or individually‐based risk assessments should treat silicosis and lung cancer as distinct entities whose cause/effect relations are not necessarily linked. Am. J. Ind. Med. 37:252–259, 2000. © 2000 Wiley‐Liss, Inc.