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Occupation and histopathology of lung cancer: A case‐control study in Rosario, Argentina
Author(s) -
Pezzotto S.M.,
Poletto L.
Publication year - 1999
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/(sici)1097-0274(199910)36:4<437::aid-ajim4>3.0.co;2-c
Subject(s) - medicine , lung cancer , confounding , adenocarcinoma , basal cell , cancer , histopathology , epidemiology , case control study , large cell , small cell carcinoma , asbestos , surgery , pathology , materials science , metallurgy
Background Male age‐adjusted lung cancer mortality rate is high in Rosario City, Argentina (62.7 per 100,000). Methods Case‐control study involving interviews with 367 male lung cancer patients and 576 controls. Results The histological distribution detected was: squamous cell 39%, adenocarcinoma 34%, small cell carcinoma 13%, and other or no specified cell type 14%. When comparing with the group unlikely to be exposed to occupational carcinogens, a 60% increase in risk was observed for the remaining occupations ( P < 0.008). Risks were high for drivers (OR=1.9, CI: 1.1–4.0), construction (OR=2.5, CI: 1.0–5.9), and agricultural workers also (OR=1.8, CI: 1.1–3.1). In regard to squamous cell carcinoma, increased risks were observed in the metal industry, particularly in welders (OR=2.9, CI: 1.0–10.1) and mechanics (OR=1.8, CI: 0.9–4.2). Smoking was not a substantial confounding effect. Conclusions Occupational exposures partly account for the high lung cancer mortality rate among male residents of Rosario City. Am. J. Ind. Med. 36:437–443, 1999. © 1999 Wiley‐Liss, Inc.