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Mortality among male licensed pesticide users and their wives
Author(s) -
Sperati Alessandra,
Rapiti Elisabetta,
Settimi Laura,
Quercia Augusto,
Terenzoni Brunella,
Forastiere Francesco
Publication year - 1999
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/(sici)1097-0274(199907)36:1<142::aid-ajim20>3.0.co;2-e
Subject(s) - medicine , pesticide , environmental health , toxicology , occupational exposure , medical emergency , agronomy , biology
Background We evaluated the mortality pattern of male licensed pesticide users and their wives in central Italy. Methods The cohort consisted of 2978 male farmers licensed for buying and handling toxic pesticides during the period 1971–1973 and 2586 farmers' wives. The Standardized Mortality Ratio (SMRs) and their 95% Confidence Intervals (95% CI) were computed on the basis of regional death rates. Results We found a lower than expected overall and cancer mortality. Non‐Hodgkin's lymphoma was increased among women (SMR = 2.29, 0.62–5.86) but not in male farmers (SMR = 0.90, 0.24–2.30), while both sexes were characterized by an increased risk of leukemia (men: SMR = 1.44, 0.69–2.64; women: SMR = 2.41, 1.04–4.76), mainly due to myeloid leukemia (men: SMR = 2.43, 0.98–5.00; women: SMR = 3.14, 1.02–7.33). Conclusions Men and women tend to share the same mortality profile. The statistically significant increase of leukemia with a threefold increased risk of the myeloid subtype only among women suggests that different pattern of exposure or biological differences between genders should be considered in evaluating health risks in agricultural settings. Am. J. Ind. Med. 36:142–146, 1999. © 1999 Wiley‐Liss, Inc.