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No evidence for the influence of HLA class II in alleles in isocyanate‐induced asthma
Author(s) -
Rihs HansPeter,
BarbalhoKrölls Tirze,
Huber Hermann,
Baur Xaver
Publication year - 1997
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/(sici)1097-0274(199711)32:5<522::aid-ajim13>3.0.co;2-4
Subject(s) - medicine , isocyanate , asthma , human leukocyte antigen , occupational asthma , atopy , allele , immunology , lung function , genotype , antigen , gene , genetics , lung , organic chemistry , chemistry , biology , polyurethane
Isocyanates are one of the main causes of occupational asthma. The aim of this investigation was to study the possible genetic background of isocyanate‐induced asthma under consideration of the atopy status and different lung function parameters. We investigated the human leukocyte antigen (HLA) genes DRB1,3,4,5, DQB1, and DQA1 in 55 isocyanate‐exposed patients with workplace‐related dyspnea (32 asthmatics, 23 nonasthmatics) and 90 nonexposed controls. In contrast to other studies, we found no significant differences for any HLA class II allele tested in our study group. Furthermore, no significant differences concerning the aspartic amino acid residue 57 of DQB1 was observed. Therefore, we are unable to confirm an involvement of a specific HLA class II allele or DQB1‐Asp57 in conferring susceptibility to isocyanate asthma in our study group. Am. J. Ind. Med. 32:522–527, 1997. © 1997 Wiley‐Liss, Inc.