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Case‐control study of malignant melanoma among employees of the Lawrence Livermore national laboratory
Author(s) -
Moore Dan H.,
Patterson H. Wade,
Hatch Fred,
Discher David,
Schneider Jeffrey S.,
Bennett Deborah,
Mendelsohn Mortimer L.
Publication year - 1997
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/(sici)1097-0274(199710)32:4<377::aid-ajim9>3.0.co;2-r
Subject(s) - medicine , melanoma , environmental health , incidence (geometry) , occupational exposure , sunbathing , dermatology , cancer research , physics , optics
During 1972 to 1977, the Lawrence Livermore National Laboratory (LLNL) experienced increased diagnosis of malignant melanoma among employees. In 1984, a report on the results of a case‐control study of 39 cases concluded that occupational factors, including exposures to ionizing radiation and to chemicals, caused the excess incidence. The study reported here, based on results from 69 case‐control pairs, re‐examines the role of the occupational factors implicated by the earlier study in melanoma causation. Results from this study suggest that constitutional factors, including skin reactivity to sunlight, sunbathing frequency, and number of moles, explain most of the excess melanoma. Exposures to occupational factors, including ionizing radiation and chemicals, were found to be no different in cases than in controls. Am. J. Ind. Med. 32:377–391, 1997. Published 1997 Wiley‐Liss, Inc.