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Occupational exposure to machining fluids and laryngeal cancer risk: Contrasting results using two separate control groups
Author(s) -
Russi Mark,
Dubrow Robert,
Flannery John T.,
Cullen Mark R.,
Mayne Susan Taylor
Publication year - 1997
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/(sici)1097-0274(199702)31:2<166::aid-ajim5>3.0.co;2-y
Subject(s) - medicine , occupational exposure , occupational cancer , machining , occupational medicine , laryngeal neoplasm , environmental health , cancer , case control study , surgery , mechanical engineering , engineering
This death certificate‐based case‐control study linked Connecticut Tumor Registry and Connecticut Division of Vital Statistics death data to determine whether machining fluid exposure is associated with laryngeal cancer risk. Laryngeal cancer cases were compared with oral cancer controls and general population controls. Level of exposure to machining fluids was imputed from the usual occupation and industry on the death certificate. Because exposure was infrequent among females, analysis was limited to males. When cases were compared to oral cancer controls, high exposure to machining fluids was associated with laryngeal cancer (odds ratio = 1.48; 95% confidence interval = 1.01–2.16), with a p–value for trend of 0.08. When cases were compared to population controls, no association between machining fluid exposure and laryngeal cancer was observed. A possible reason for the contrasting results, other than chance, is that exposure data quality for the cases and oral cancer controls may have differed from that of the population controls. Am. J. Ind. Med. 31:166–171, 1997. © 1997 Wiley‐Liss, Inc.