Premium
Multi‐state models for bleeding episodes and mortality in liver cirrhosis
Author(s) -
Andersen Per Kragh,
Esbjerg Sille,
Sørensen Thorkild I. A.
Publication year - 2000
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/(sici)1097-0258(20000229)19:4<587::aid-sim358>3.0.co;2-0
Subject(s) - cirrhosis , survival analysis , statistics , econometrics , marginal distribution , medicine , computer science , mathematics , random variable
Data from a controlled clinical trial in liver cirrhosis are used to illustrate that multi‐state models may be a useful tool in the analysis of data where survival is the ultimate outcome of interest but where intermediate, transient states are identified. We compare models for the marginal survival time distribution with models including transient states, both with respect to their clinical interpretation and with respect to the precision of survival probability estimates obtained from the various models. Copyright © 2000 John Wiley & Sons, Ltd.