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Genetic mapping of complex traits
Author(s) -
Olson Jane M.,
Witte John S.,
Elston Robert C.
Publication year - 1999
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/(sici)1097-0258(19991115)18:21<2961::aid-sim206>3.0.co;2-u
Subject(s) - inheritance (genetic algorithm) , linkage disequilibrium , family based qtl mapping , linkage (software) , quantitative trait locus , inclusive composite interval mapping , gene mapping , trait , randomness , association mapping , biology , genetic analysis , genetic linkage , genetics , human genome , computational biology , evolutionary biology , genome , computer science , gene , single nucleotide polymorphism , haplotype , allele , statistics , genotype , mathematics , chromosome , programming language
Statistical genetic mapping methods are powerful tools for finding genes that contribute to complex human traits. Mapping methods combine knowledge of the biological mechanisms of inheritance and the randomness inherent in those mechanisms to locate, with increasing precision, trait genes on the human genome. We provide an overview of the two major classes of mapping methods, genetic linkage analysis and linkage disequilibrium analysis, and related concepts of genetic inheritance. Copyright © 1999 John Wiley & Sons, Ltd.