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Adverse effects of chorionic villus sampling: a meta‐analysis
Author(s) -
Brumback Babette A.,
Holmes Lewis B.,
Ryan Louise M.
Publication year - 1999
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/(sici)1097-0258(19990830)18:16<2163::aid-sim180>3.0.co;2-h
Subject(s) - chorionic villus sampling , meta analysis , chorionic villi , random effects model , computer science , sampling (signal processing) , randomized controlled trial , medicine , statistics , pregnancy , prenatal diagnosis , mathematics , fetus , biology , genetics , filter (signal processing) , computer vision
Meta‐analysis is a popular tool for combining evidence from several related studies. The technique is usually used to combine randomized clinical trials, case‐control studies or prospective studies where each study has its own exposed and unexposed groups. By including separate ‘study effects’ (either fixed or random), one can combine information about differences between control and exposed groups, while still allowing for study heterogeneity. In this paper, we extend existing methods to combine studies of disparate designs, where some studies do not include concurrent controls. We apply the methods to a meta‐analysis of the association of prenatal testing via chorionic villus sampling with the occurrence of terminal transverse limb defects. Copyright © 1999 John Wiley & Sons, Ltd.