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Dose response studies: how do we make them conclusive?
Author(s) -
Källén Anders,
Larsson Per
Publication year - 1999
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/(sici)1097-0258(19990330)18:6<629::aid-sim72>3.0.co;2-y
Subject(s) - computer science , medicine , econometrics , mathematics
In this paper we discuss how to make meaningful use of a dose response study. It is argued that concepts like the minimal effective dose are not clinically meaningful and that the purpose of a dose response study should be to identify the drug potency in relation to a known active control. We also discuss various ways of carrying out the analysis. Copyright © 1999 John Wiley & Sons, Ltd.