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Redesign of trials under different enrolment mixes
Author(s) -
Meinert Curtis L.
Publication year - 1999
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/(sici)1097-0258(19990215)18:3<241::aid-sim17>3.0.co;2-o
Subject(s) - clinical trial , computer science , medicine , econometrics , statistics , mathematics
A few large multi‐centre male‐only heart trials done in the 1970s and 1980s have been seen as ill‐conceived because they did not include females. The purpose here is to revisit two of those trials and to consider consequences in terms of cost and power had they been designed to include females. Copyright © 1999 John Wiley & Sons, Ltd.