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Exploratory thoughts on clinical trials with utilities
Author(s) -
Tan S. B.,
Smith A. F. M.
Publication year - 1998
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/(sici)1097-0258(19981215)17:23<2771::aid-sim42>3.0.co;2-9
Subject(s) - clinical trial , computer science , exploratory data analysis , exploratory research , econometrics , medicine , economics , data mining , sociology , anthropology
We consider problems of choice of sample size and allocation in the clinical trials context when utilities are explicitly taken into account. In particular, we consider utilities of benefits and side‐effects (and their trade‐offs), as well as utility functions that trade‐off scientific and ethical concerns. © 1998 John Wiley & Sons, Ltd.