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Some controversies in planning and analysing multi‐centre trials
Author(s) -
Senn Stephen
Publication year - 1998
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/(sici)1097-0258(19980815/30)17:15/16<1753::aid-sim977>3.0.co;2-x
Subject(s) - computer science , management science , operations research , economics , mathematics
It is shown that a rational approach to planning multi‐centre trials will lead to an unequal distribution of patients across centres. Consequently different approaches to estimation will yield different estimates. However, some such approaches are not reasonable and it is concluded that multi‐centre trials are less problematic than is commonly supposed. © 1998 John Wiley & Sons, Ltd.