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ANALYSIS OF SEROLOGICAL SURVEYS USING MIXTURE MODELS: APPLICATION TO A SURVEY OF PARVOVIRUS B19
Author(s) -
GAY NIGEL J.
Publication year - 1996
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/(sici)1097-0258(19960730)15:14<1567::aid-sim289>3.0.co;2-g
Subject(s) - serology , parvovirus , antibody , maximum likelihood , statistics , medicine , virology , immunology , mathematics , virus
A method for the analysis of age stratified antibody prevalence surveys is developed. The age specific distribution of the quantitative results of serological antibody tests is modelled as a mixture of seropositive and seronegative components. This yields maximum likelihood estimates of the prevalence at each age. The method is illustrated using data from a previously reported survey of antibody to parvovirus B19.