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GLOBAL TESTS FOR ANALYSIS OF MULTIPLE TUMOUR DATA FROM ANIMAL CARCINOGENICITY EXPERIMENTS
Author(s) -
CHEN JAMES J.
Publication year - 1996
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/(sici)1097-0258(19960615)15:11<1217::aid-sim229>3.0.co;2-4
Subject(s) - logistic regression , carcinogen , bioassay , maximum tolerated dose , animal testing , medicine , statistics , toxicology , biology , mathematics , cancer , ecology , genetics
This paper presents test procedures for testing of the overall dose effect at every tumour type/site simultaneously in a chronic animal carcinogenicity bioassay. I derive global tests of the tumour prevalence rates and the tumour onset rates using the generalized estimating equations approach. The test is based on the model of a common dose effect alternative. I used the logistic regression model for simultaneous testing of non‐lethal tumours, and the Poly‐3 test for testing of mixtures of lethal or non‐lethal tumours of different types/sites. An application illustrating the proposed tests concerns analysis of a carcinogenicity experiment designed to study the dose response of hepatocellular and bladder tumours to 2‐acetylaminofluorene (2‐AAF) exposure.