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A MODEL FOR CROSS‐OVER TRIALS EVALUATING THERAPEUTIC PREFERENCES
Author(s) -
LINDSEY J. K.,
JONES B.
Publication year - 1996
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/(sici)1097-0258(19960229)15:4<443::aid-sim161>3.0.co;2-i
Subject(s) - logistic regression , asthma , clinical trial , preference , econometrics , logistic distribution , statistics , medicine , computer science , mathematics
A preference trial is a special form of cross‐over trial where clinical conditions determine when patients change treatment, in a prescribed order. This can be modelled using a geometric distribution. The model can be simply fitted using standard logistic regression methodology. The procedure is applied to a trial studying the effects of bronchodilators in the treatment of chronic asthma.