Premium
Aspartame degradation study using electrospray ionization mass spectrometry
Author(s) -
Pattanaargson Supason,
Sanchavanakit Chatchapol
Publication year - 2000
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(20000615)14:11<987::aid-rcm976>3.0.co;2-1
Subject(s) - chemistry , aspartame , fragmentation (computing) , electrospray ionization , chromatography , mass spectrometry , phenylalanine , electrospray , desorption electrospray ionization , ionization , degradation (telecommunications) , organic chemistry , chemical ionization , amino acid , biochemistry , ion , telecommunications , computer science , operating system
Electrospray mass spectrometry was used to simultaneously determine aspartame (APM) and five of its degradation products; aspartic acid, aspartylphenylalanine, 5‐benzyl‐3,6‐dioxo‐2‐piperazieacetic acid (diketopiperazine), phenylalanine, and phenylalanine methyl ester. Under the ionization conditions used, there was no interfering fragmentation for any of the six compounds, i.e., no fragmentation of the compound being tested into other species also being monitored. A study of APM degradation in solution at various pH's and at various temperatures using this method was performed. Copyright © 2000 John Wiley & Sons, Ltd.